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Цитологія і генетика
 
 
Цитологія і генетика 2025, том 59, № 5, 85-87
Cytology and Genetics 2025, том 59, № 5, 516–525, doi: https://www.doi.org/10.3103/S0095452725050093

The potential impact of microrna­related functional polymorphisms in the pathogenesis of coronary heart disease

Haq T.U., Ali Y., Rehman S.U., Aziz T., Albekairi T.H., Shah A.A.

  1. Department of Biotechnology, University of Malakand, Khyber Pakhtunkhwa, Pakistan
  2. Department of Biotechnology, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan
  3. School of Biomedical Sciences, Chinese University of Hong Kong, NT, Hong Kong
  4. University of Ioannina, Greece
  5. King Saud University, Saudi Arabia

РЕЗЮМЕ. МікроРНК (miRNA) широко відомі як генні регулятори різних захворювань. Однонуклеотидний поліморфізм (SNP) у генах мікроРНК впливає на транскрипцію, дозрівання, специфічність мішені та взаємодію мікроРНК, сприяючи розвитку ішемічної хвороби серця (ІХС). Представлене дослідження типу «випадок-контроль» було розроблено для визначення ролі rs2292832, rs3746444, rs11614913, rs1044165 та rs767649 як факторів ризику ІХС у пакистанській популяції за допомогою аналізу TaqMan. Метою дослідження було вивчити асоціацію п’яти міРНК SNP – rs2292832, rs3746444, rs11614913, rs1044165 та rs767649 – з ризиком ІХС у пакистанській популяції за допомогою аналізу TaqMan. Серед них rs3746444 показав значну асоціацію з ІХС за кодомінантним, домінантним, гетерозиготним та адитивним типами успадкування. Аналогічно, rs11614913 був пов’язаний з ІХС за кодомінантною, домінантною, рецесивною та адитивною моделями. SNP rs767649 асоціювався з ІХС за кодомінантною, домінантною, рецесивною, гетерозиготною та адитивною моделями. Сильний зв’язок між rs1044165 та ІХС спостерігався за гетерозиготною моделлю. Варіанти в MIR499A, MIR196A2, MIR155 і MIR223 виявилися значущими генетичними факторами ризику ІХС, тоді як MIR149 не продемонстрував значущої асоціації в цій когорті. Ці результати свідчать про потенційну роль поліморфізмів міРНК у патогенезі ІХС, однак для підтвердження цих асоціацій необхідні подальші дослідження з більшими розмірами вибірок.

Ключові слова: мікроРНК, однонуклеотидний поліморфізм, ішемічна хвороба серця, аналіз TaqMan

Цитологія і генетика
2025, том 59, № 5, 85-87

Current Issue
Cytology and Genetics
2025, том 59, № 5, 516–525,
doi: 10.3103/S0095452725050093

Повний текст та додаткові матеріали

Цитована література

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