РЕЗЮМЕ. Розвиток технологій перепрограмування клітин революціонізував ландшафт регенеративної медицини та досліджень лікарських засобів. У цьому огляді детально розглядається процес перепрограмування соматичних клітин у стовбурові, зокрема індуковані плюрипотентні стовбурові клітини (iPSC), та простежується їхня еволюція з плином часу. Спочатку огляд окреслює відмінності між звичайними та стовбуровими клітинами. Згодом він заглиблюється в історичну траєкторію ембріональних стовбурових клітин (ЕСК) та iPSC. Досліджується ключова роль перепрограмування соматичних клітин у фармацевтичній біотехнології, висвітлюється її застосування в моделюванні захворювань, розробці ліків, регенеративній медицині та персоналізованій терапії. Огляд дає уявлення про фундаментальні принципи методів перепрограмування, зокрема, генерацію iPSC, фактори транскрипції, епігенетичні модифікації та неінтегративні методи перепрограмування. Особливу увагу приділено методам редагування геному, таким як CRISPRCas9, TALEN, ZFN та редагування основ, з огляду на їхню першочергову важливість для клітинного перепрограмування. Зрештою в огляді розглядаються різноманітні способи, за допомогою яких клітинне перепрограмування може омолодити мертві клітини на стовбурові, що підкреслює трансформаційний потенціал цієї технології в різних галузях біомедицини. Висвітлюючи багатогранні ефекти й можливості перепрограмування соматичних клітин, цей огляд має на меті слугувати цінним ресурсом для науковців і практиків у галузі клітинної та молекулярної біології.
Ключові слова: індуковані плюрипотентні стовбурові клітини (iPSC), клітинне перепрограмування, стовбурові клітини, соматичні клітини, регенеративна медицина

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