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Association of MYNN, TERT and TERC gene polymorphisms with prostate cancer in Turkish population

F. Polat, S. B. Dİler, G. Bİngöl

Оригінальна работа 




РЕЗЮМЕ. Мета цього дослідження полягала у визначенні можливого зв’язку між розвитком раку простати і поліморфізмом MYNN rs10936599, TERC rs2293607 та hTERT MNS16A серед населення Туреччини. Учасниками дослідження були 77 осіб з раком простати і 116 здорових добровольців без раку в анамнезі. Генотипування проводили за допомогою полімеразно-ланцюгової реакції (ПЛР) та поліморфізму довжин рестрикційних фрагментів (ПДРФ). Оцінку отриманих результатів проводили за допомогою критерія хі-квадрат та безумовного логістичного регресивного аналізу. Під час дослідження було виявлено, що генотип GG поліморфізму TERC rs2293607, генотип VNTR-243/243 поліморфізму TERT MNS16A та алель 243 є статистично значимими для груп пацієнтів та контролю (ORc = 3,250, 95%CI = 1,176–8,980, pc = 0,023; ORc = 3,09, 95% CI = 1,238–7,717, pc = 0,016; OR = 0,638, 95%CI = 0,416–0,978, p = 0,038). З іншого боку, не було виявлено суттєвого зв’язку між поліморфізмом MYNN rs109365999 та раком простати серед населення Туреччини. Отже, отримані дані свідчать про те, що поліморфізми TERC rs2293607 та TERT MNS16A VNTR-243/243 можуть бути потенційними факторами ризику розвитку раку простати серед населення Туреччини і можуть вважатися прогностичними маркерами.

Ключові слова: MYNN, TERT, TERC, рак простати, населення Туреччини

Цитологія і генетика 2020, том 54, № 6, C. 70-72

  1. Department of Mathematics and Science Education, Faculty of Education, Kocaeli University, Kocaeli, Turkey
  2. Department of Biotechnology, Faculty of Science and Letters, Nigde Ömer Halisdemir University, Niğde, Turkey
  3. Biomedical Engineering, Faculty of Engineering and Natural Sciences, Ankara Yıldırım Beyazıt University, Ankara, Turkey

E-mail: fikriyepolat gmail.com

F. Polat, S. B. Dİler, G. Bİngöl Association of MYNN, TERT and TERC gene polymorphisms with prostate cancer in Turkish population, Цитологія і генетика., 2020, том 54, № 6, C. 70-72.

В "Cytology and Genetics". Якщо тільки можливо, цитуйте статтю по нашій англомовній версії:
F. Polat, S. B. Diler & G. Bingöl Association of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population, Cytol Genet., 2020, vol. 54, no. 6, pp. 574–581
DOI: 10.3103/S0095452720060080


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