ISSN 0564-3783  

Main page
Information to authors
Editorial board
Mobile version

In Ukrainian

Export citations

Association of MYNN, TERT and TERC gene polymorphisms with prostate cancer in Turkish population

F. Polat, S. B. Dİler, G. Bİngöl


This study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10936599, TERC rs2293607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (ORc = 3.250, 95%CI = 1.176–8.980, pc = 0.023; ORc = 3.09, 95%CI = 1.238–7.717, pc = 0.016; OR = 0.638, 95%CI = 0.416-0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.

Key words: MYNN, TERT, TERC, prostate cancer, Turkish population

Tsitologiya i Genetika 2020, vol. 54, no. 6, pp. 70-72

  1. Department of Mathematics and Science Education, Faculty of Education, Kocaeli University, Kocaeli, Turkey
  2. Department of Biotechnology, Faculty of Science and Letters, Nigde Ömer Halisdemir University, Niğde, Turkey
  3. Biomedical Engineering, Faculty of Engineering and Natural Sciences, Ankara Yıldırım Beyazıt University, Ankara, Turkey

E-mail: fikriyepolat

F. Polat, S. B. Dİler, G. Bİngöl Association of MYNN, TERT and TERC gene polymorphisms with prostate cancer in Turkish population, Tsitol Genet., 2020, vol. 54, no. 6, pp. 70-72.

In "Cytology and Genetics":
F. Polat, S. B. Diler & G. Bingöl Association of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population, Cytol Genet., 2020, vol. 54, no. 6, pp. 574–581
DOI: 10.3103/S0095452720060080


1. Apolonio, J.D., Campbell, B., Lee, D., et al., A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study, Oncotarget, 2016, vol. 7, no. 36, pp. 57726-36.

2. Yılmaz, B. and Sarıkaya, D., Incidence and risk factors for prostate cancer, Turk. Klin. Med. Oncol., 2017, vol. 10, no. 4, pp. 337–342.

3. He, K., Hu, H., Ye, S., et al., The effect of metformin therapy on incidence and prognosis in prostate cancer: a systematic review and meta-analysis, Sci. Rep., 2019, vol. 9, no. 1, p. 2218.

4. Alliel, P. M., Seddiqi, N., Goudou, D., et al., Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle, Biochem. Biophys. Res. Commun., 2000, vol. 273, no.1, pp. 385–391.

5. Guo, X., Li, M., Gao, P., et al., Novel splice isoforms of pig myoneurin and their diverse mRNA expression patterns, Asian-Aust. J. Anim. Sci., 2018, vol. 31 no. 10, pp. 1581–1590.

6. Njajou, O.T., Blackburn, E.H., Pawlikowska, L., et al., A Common variant in the telomerase RNA component is associated with short telomere length, PLoS One, 2010, vol. 27, no. 9, p. e13048.

7. Jones, A.M., Beggs, A.D., Carvajal-Carmona, L., et al., TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres, Gut, 2012, vol. 61, no. 2, pp. 248–254.

8. Folini, M., Brambilla, C, Villa, R., et al., Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells, Eur. J. Cancer, 2005, vol.41, no. 4, pp. 624–634.

9. Wang, Y., Hu, Z., Liang, J., et al., A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women, Carcinogenesis, 2008, vol. 29, no. 6, pp.1197–1201.

10. Essa, E.S., and Alagizy, H.A., Association of MNS16A VNTR and hTERT rs2736098: G>A polymorphisms with susceptibility to diffuse large B-cell lymphoma, Tumori J., 2018, vol. 104, no. 3, pp. 165–171.

11. Wang, L., Soria, J.C., Chang, Y.S., et al., Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer, Oncogene, 2003, vol. 22, no. 46, 7123–7129.

12. Hofer, P., Baierl, A., Feik, E., et al., MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer, Carcinogenesis, 2011, vol. 32, no. 6, 866–871.

13. Hofer, P., Zerelles, J., Baierl, A., et al., MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility, Mutagenesis, 2013, vol. 28, no. 3, pp. 301–306.

14. Graham, M.K. and Meeker, A., Telomeres and telomerase in prostate cancer development and therapy, Nat. Rev. Urol., 2017, vol. 14, no. 10, pp. 607–619.

15. Sheng X, Zhang L, Luo D, et al., A common variant near TERC and telomere length are associated with susceptibility to childhood acute lymphoblastic leukemia in Chinese, Leuk. Lymphoma, 2012, vol. 53, no. 9, pp. 1688–1692.

16. Soder, A.I., Hoare, S.F., Muir, S., et al., Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer, Oncogene, 1997, vol. 14 no. 9, pp. 1013–1021.

17. Figueroa, J. D., Ye, Y., Siddiq, A., et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk, Hum. Mol. Genet., 2014, vol. 23, no. 5, pp. 1387–1398.

18. Polat, F., Yilmaz, M., Budak, D.S., The association of MYNN and TERC gene polymorphisms and bladder cancer in a Turkish Population, Urol. J., 2019, vol. 16, no. 1, pp. 50–55.

19. Diler, S.B. and Öden, A., The T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in prostate cancer cases, Genetica, 2016, vol. 52, no. 2, pp. 220–225.

20. Koressaar, T. and Remm, M., Enhancements and modifications of primer design program Primer3, Bioinformatics, 2007, vol. 23, no. 10, pp. 1289–1291.

21. Untergrasser, A., Cutcutache, I., Koressaar, T., Ye, J., et al., Primer3—new capabilities and interfaces, Nucleic Acids Res., 2012, vol. 40, no. 15, e115.

22. Campa, D., Matarazzi, M., Greenhalf, W., et al., Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study, Int. J. Cancer, 2019, vol. 144, no. 6, pp. 1275–1283.

23. Machiela, M.J., Hofmann, J.N., Carreras-Torres., R., et al., Genetic variants related to longer telomere length are associated with increased risk of renal cell carcinoma, Eur. Urol., 2017, vol. 72, no. 5, pp. 747–754.

24. Wang, M., Chu, H., Lv, Q., et al., Cumulative effect of genome-wide association study-identified genetic variants for bladder cancer, Int. J. Cancer, 2014, vol. 135, no. 11, pp. 2653–2660.

25. Muskens, I.S., Hansen, H.M., Smirnov, I.V., et al., Genotypicially-estimated leukocyte telomere length is associated with increased meningioma risk, J. NeuroOncol., 2019, vol. 142, no. 3, pp. 479–487.

26. Houlston, R.S., Cheadle, J., Dobbins, S.E., et al., Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33, Nat. Genet., 2010, vol. 42, no. 11, pp. 973–977.

27. Carvajal-Carmona, L.G., Zauber, A.G., Jones, A.M., et al., Much of the population genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas, Gastroenterology, 2013, vol. 144, no. 1, pp. 53–55.

28. Song, N., Kim, K., Shin, A., et al., Colorectal cancer susceptibility loci and influence on survival Nan, Genes Chromosomes Cancer, 2018, vol. 57, no. 12, pp. 630–637.

29. Ye, G., Tan, N., Meng, C., et al., Genetic variations in TERC and TERT genes are associated with lung cancer risk in a Chinese Han population, Oncotarget, 2017, vol. 8, no. 16, pp. 110145–110152.

30. Chub, D., Weinhold, N., Broderick, P., et al., Common variation at 3q26.2, 6p21.33 and 22q13.1 influences Multiple Myeloma Risk, Nat. Genet., 2016, vol. 45, no. 10, pp. 1221–5.

31. Cao, W., Li, X., Zhang, X., Zhang, J., et al., No causal effect of telomere length on ischemic stroke and its subtypes: a Mendelian randomization study, Cells, 2019, vol. 8, no. 2, p. 159.

32. Daniel, M., Peek, G.W., and Tollefsbol, T.O., Regulation of the human catalytic subunit of telomerase (hTERT), Gene, 2012, vol. 498, no. 2, pp. 135–146.

33. Wysoczanska, B., Wrobel, T., Dobrzynska, O., et al., Role of the functional MNS16A VNTR-243 variant of the human telomerase reverse transcriptase gene in progression and response to therapy of patients with non-Hodgkin’s B-cell lymphomas, Int. J. Immunogenet., 2015, vol. 42, no. 2, pp. 100–105.

34. Hofer, P., Z?chmeister, C., Behm, C., et al., MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer, Oncotarget, 2017, vol. 8, no. 17, pp. 28021–28027.

35. Wang, L., Wang, L.E., Mao, L., et al., A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer, Clin. Cancer Res., 2010, vol. 16, no. 14, pp. 3779–3785.

36. Jin, G., Yoo, S. S., Cho, S. et al., Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer, Cancer Sci., 2011, vol. 102, no. 1, pp. 144–149.

37. Chang, C.C., Yu, M.C., Bai, K.J., et al., The analysis between functional human telomerase reverse transcriptase MNS16A polymorphisms and the risk of developing non-small cell lung cancer in the Taiwanese population, J. Exp. Clin. Med., 2011, vol. 3, no. 6, pp. 293–295.

38. Carpentier, C., Lejeune, J., Gros, F., et al., Association of telomerase gene hTERT polymorphism and malignant gliomas, J. Neurooncol., 2007, vol. 84, no. 3, pp. 249–253.

39. Zhang, Y., Zhang, H., Zhai, Y., et al., A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population, BMC Med., 2011, vol. 9, p. 106.

Copyright© ICBGE 2002-2021 Coded & Designed by Volodymyr Duplij Modified 21.09.21