Обзор посвящен особенностям развития хронического вирусного гепатита С в организме при наличии генетического дефекта в гене наследственного гемохроматоза (HFE), контролирующем метаболизм железа. Обсуждается влияние мутаций гена HFE на: подверженность пациента вирусной агрессии, развитие патологических процессов в печени при хроническом вирусном гепатите С, в том числе наиболее тяжелых осложнений – цирроза печени и гепатоклеточной карциномы, отзывчивость пациентов – носителей мутаций на терапию вирусного гепатита С.
РЕЗЮМЕ. Огляд присвячений особливостям розвитку хронічного вірусного гепатиту С в організмі при наявності генетичного дефекту в гені спадкового гемохроматозу (HFE), що контролює метаболізм заліза. Обговорюється вплив мутацій гена HFE на: схильність пацієнта до вірусної агресії; розвиток патологічних процесів у печінці при хронічному вірусному гепатиті С, в тому числі найбільш важких ускладнень – цирозу печінки і гепатоклітинної карциноми, чутливість пацієнтів – носіїв мутацій до терапії вірусного гепатиту С.
Ключові слова: мутации гена HFE, вирус гепатита С, хроническая вирусная инфекция, нарушение обмена железа
мутації гена HFE, вірус гепатиту С, хронічна вірусна інфекція, порушення обміну заліза
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