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eNOS and VEGF variants might increase the risk of pancreatic cancer

Dagmura H., Yigit S., Gumusay O., Nursal A.F., Daldal E., Karakus N.

 




Endothelial nitric oxide synthase (eNOS) is essential in chronic inflammation and carcinogenesis. The association between variants in vascular endothelial growth factor (VEGF) and several cancers still remains uncertain.We studied whether there is a relation between eNOS/VEGF variants and risk of pancreatic cancer (PC). This prospective casecontrol study included 76 PC patients (28 women and 48 men) and 100 healthy controls. Blood samples from all participants were genotyped for eNOS variable number tandem repeat(VNTR) and VEGF insertion/deletion (I/D) variants by PCR. There was a significant difference between groups for the eNOS intron 4 VNTR genotype distributions (p = 0.01). eNOS 4a/4b and 4b/4b genotypes were higher in patients with PC group compared to controls while eNOS 4a/4b genotype was more prevalent in control group than in patient group. Significant differences were observed between groups for the VEGF I/D variant genotype and allele frequencies (p ˂ 0.00, and p ˂ 0.00). VEGF I/D variant I/I genotype and I allele increased in patient group than controls. A statistically significant association was observed when the patients were compared with the controls according to D/D+D/I versus D/D (p ˂ 0.00, OR: 0.094, 95 % CI: 0.030.22) We provided evidence that eNOS VNTR and VEGF I/D variants might influence the development of PC.

Key words: pancreatic cancer, eNOS, VEGF, variant

Tsitologiya i Genetika 2021, vol. 55, no. 2, pp. 72-74

  1. MD, Department of General surgery and surgical oncology, Gaziosmanpasa University, School of Medicine, Kaleardi Mah. Tokat (60250), Turkey
  2. Associate Professor, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
  3. Associate professor of Medical Oncology, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
  4. Associate Professor of Genetics, Hitit University, Department of Genetics, Corum, Turkey
  5. Assistant professor of General Surgery, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
  6. Associate Professor of Medical Biology, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey

E-mail: hassen hacettepe.edu.tr, serbulent.yigit gmail.com, ozgebostankolu hotmail.com, feyda.nursal gmail.com, emindaldal hotmail.com, nevinbalci hotmail.com

Dagmura H., Yigit S., Gumusay O., Nursal A.F., Daldal E., Karakus N. eNOS and VEGF variants might increase the risk of pancreatic cancer, Tsitol Genet., 2021, vol. 55, no. 2, pp. 72-74.

In "Cytology and Genetics":
Hasan Dagmura, Serbulent Yigit, Ozge Gumusay, Ayse Feyda Nursal, Emin Daldal & Nevin Karakus eNOS and VEGF Variants Might Increase the Risk of Pancreatic Cancer, Cytol Genet., 2021, vol. 55, no. 2, pp. 177182
DOI: 10.3103/S0095452721020031


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