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Relationship between the prevalence of ACE1 I/D polymorphism genotype ii and COVID-19 morbidity, mortality in Ukraine and in some Europe countries
SUMMARY. Coronavirus disease (COVID-19), which was first re-corded in China in December 2019, quickly spread to other countries and in a short period of time, the local outbreak escalated into a pandemic. There are significantly more cases of COVID-19 morbidity and mortality in European countries than in East Asia, where the disease was first detected. Such population differences are unique, especially for SARS-CoV-2 and are due to both socio-behavioral differences and features of the gene pool of the population of different countries. For infectious diseases, such as COVID-19, an important point is the genetic characteristics of individuals, which can determine its resistance or sus-ceptibility to infection. Therefore, studies of the factors of hereditary predisposition to SARS-CoV-2 infection, as well as severity and mortality are extremely relevant. After genotyping among the healthy population of Ukraine and collecting relevant data from some Euro-pean countries, we determined the correlation between morbidity, mortality from COVID-19 and the prevalence of genotype II in the populations of Ukraine and several European countries. There was a negative correlation between the carrier of genotype II and susceptibility to SARS-CoV-2 infection per 1 million population (R = –0.53, p < 0.05), so individuals with genotype II can be considered more resistant to infection SARS-CoV-2. Further study of the role of allelic variants of the ACE1 gene in the development of severity and complications affected patients of COVID-19, are promising for iden-tified of genetic markers for development of personalized therapy.
Key words: COVID-19, SARS-CoV-2, morbidity, ACE1 gene, hereditary predisposition
Tsitologiya i Genetika 2021, vol. 55, no. 5, pp. 28-35
E-mail: livshits edu.imbg.org.ua, tatti.my gmail.com, tetiana.umanets gmail.com, krasnenkovd gmail.com, podolskyy.v ukr.net
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