TSitologiya i Genetika 2021, vol. 55, no. 4, 26-33
Cytology and Genetics 2021, vol. 55, no. 4, 317–323, doi: https://www.doi.org/10.3103/S0095452721040022

The level of expression NOS2 and NFKB1 Genes in esophageal alkaline burns and when melanin is administered

Chornenka N.M., Raetska Ya.B., Huet A.S., Beregova T.V., Savchuk O.M., Ostapchenko L.I.

  • Educational and Scientific Center «Institute of Biology and Medicine», Taras Shevchenko National University of Kyiv, Ukraine

SUMMARY. In this study, we have shown an increase in the expression of pro-inflammatory agents – Nos2 and Nfkb1 genes – in the blood and mucous membrane of the esophagus under conditions of the 2nd degree esophageal alkaline burn (EAB 2). It was found that under AEB 2, the activity of eNOS and iNOS increased both in the blood and mucous membrane of the esophagus. After the introduction of melanin, there was a decrease in the expression of Nos2 and Nfkb1 genes in the blood and esophageal tissues as compared with AEB 2. Also, there was a decrease in the activity of eNOS and iNOS as compared with AEB 2, indicating the anti-inflammatory properties of this compound and the possibility of using melanin as a substance that promotes faster healing of chemical burns of the esophagus and prevents post-burn complications.

Keywords: alkaline burn of the esophagus, gene expression Nos2, Nfkb1, nitric oxide, melanin

TSitologiya i Genetika
2021, vol. 55, no. 4, 26-33

Current Issue
Cytology and Genetics
2021, vol. 55, no. 4, 317–323,
doi: 10.3103/S0095452721040022

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