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Tlr2, Tjp1 genes expression during restoration of skin integrity

Huet ., Dvorshchenko ., Taburets O., Grebinyk D., Beregova T., Ostapchenko L.


SUMMARY. The decrease of Tjp1 gene expression against the background of activation of free radical processes (increase in the content of superoxide anion-radical) was observed during healing of full-thickness skin wounds in rats. The restoration of the expression level of this gene may be mediated by an increase in the expression level of Tlr2 gene. The level of Tjp1 gene expression as well as the content of the superoxide anion radical, was closer to the control values at the specified wound pattern in the absence of Tlr2 gene overexpression upon the treatment with melanin during restoration of skin integrity.

Key words: Tjp1, Tlr2 gene expression, full-thickness skin wound, melanin

Tsitologiya i Genetika 2020, vol. 54, no. 6, pp. 45-53

  • Educational and Scientific Center Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Str., Kyiv 01601

E-mail: alevtina.dranitsina

Huet ., Dvorshchenko ., Taburets O., Grebinyk D., Beregova T., Ostapchenko L. Tlr2, Tjp1 genes expression during restoration of skin integrity, Tsitol Genet., 2020, vol. 54, no. 6, pp. 45-53.

In "Cytology and Genetics":
A. Huet, K. Dvorshchenko, O. Taburets, D. Grebinyk, T. Beregova & L. Ostapchenko Tlr2 and Tjp1 Genes Expression during Restoration of Skin Integrity, Cytol Genet., 2020, vol. 54, no. 6, pp. 539545
DOI: 10.3103/S0095452720060122


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