Evaluation of the role of polymorphism rs2010963 of VEGF gene in the development of rosaсea and its relationship with clinical forms of the disease

Babajanov O.A., Karimov Ch.Ya., Arifov S.S., Boboev K.T.

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SUMMARY. The frequency of genotypic variants of the rs2010963 polymorphism of the gene for vascular endothelial growth factor (VEGF) was analyzed in 140 patients with rosacea in 145 conditionally healthy persons of Uzbek nationality. It was shown that the distribution of genotypes in the studied groups corresponded to the Hardy-Weinberg equilibrium (p > 0,05). Significant differences in the frequency of occurrence for rs2010963 alleles of the VEGF gene were found between groups of patients with rosacea with different clinical forms of the disease and a group of conditionally healthy individuals (P < 0,05). Carrying a functionally unfavorable allele 634C VEGF in the hetero- or homozygous variant significantly increases the risk of developing rosacea. The data obtained indicate the association of this DNA locus with the formation of rosacea in the Uzbek population.

Key words: rosacea, erythematous form, papulopustular form, VEGF gene, rs2010963 polymorphism

Tsitologiya i Genetika 2019, vol. 53, no. 3, pp. 65-71

E-mail: kity_1508 mail.ru, abdukadir_babaev mail.ru, arifov1961 rambler.ru

Babajanov O.A., Karimov Ch.Ya., Arifov S.S., Boboev K.T. Evaluation of the role of polymorphism rs2010963 of VEGF gene in the development of rosaсea and its relationship with clinical forms of the disease, Tsitol Genet., 2019, vol. 53, no. 3, pp. 65-71.

In "Cytology and Genetics":
O. A. Babadjanov, H. Ya. Karimov, S. S. Arifov, K. T. Boboev Evaluation into the Role of the VEGF Gene Polymorphism rs2010963 in the Development of Rosacea and its Relationship with Clinical Subtypes of the Disease, Cytol Genet., 2019, vol. 53, no. 3, pp. 233–238
DOI: 10.3103/S0095452719030083

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