Comparison of the modifying effect of astaxanthin on the development of radiation-induced chromosome instability in human blood lymphocytes, exposed in vitro on different stages of their cell cycle

Kurinnyi D.A., Rushkovskyi S.R., Demchenko O.M., Dybska O.B., Pilinska M.A.

SUMMARY. The paper presents the results of comparing the peculiarities of the modifying effects of astaxanthin (20,0 µg/ml) on the γ-quanta-induced chromosomal instability in human peripheral blood lymphocytes exposed in vitro (1,0 Gy) on G₀, S and G₂ stages of the cell cycle. The absence of astaxanthin effect on both the mean frequencies and spectra of radiation-induced chromosomal aberrations (p > 0,05) in cells irradiated on S and G₂ stages of the mitotic cycle was demonstrated. The powerful protective effect of astaxanthin on the level of radiation-induced chromosomal instability (p < 0,001) was observed only in cells that were irradiated on the G₀ stage. Thus, the dependence of radioprotective effect of astaxanthin on the stage of the mitotic cycle on which the cells were exposed to γ-quanta was established.

Tsitologiya i Genetika 2018, vol. 52, no. 5, pp. 62-68

E-mail: kurinnyi.d gmail.com; rsr ukr.net; _demchenko ukr.net; oreh­dss ukr.net; pww ukr.net

Kurinnyi D.A., Rushkovskyi S.R., Demchenko O.M., Dybska O.B., Pilinska M.A. Comparison of the modifying effect of astaxanthin on the development of radiation-induced chromosome instability in human blood lymphocytes, exposed in vitro on different stages of their cell cycle, Tsitol Genet., 2018, vol. 52, no. 5, pp. 62-68.

In "Cytology and Genetics":
D. A. Kurinnyi, S. R. Rushkovskyi, O. M. Demchenko, O. B. Dybska, M. A. Pilinska Comparison of the Modifying Action of Astaxanthin on the Development of Radiation-Induced Chromosome Instability in Human Blood Lymphocytes Irradiated in vitro at Different Cell Cycle Stages, Cytol Genet., 2018, vol. 52, no. 5, pp. 368–373
DOI: 10.3103/S0095452718050055