TSitologiya i Genetika 2017, vol. 51, no. 3, 79-81
Cytology and Genetics 2017, vol. 51, no. 3, 214–220, doi: https://www.doi.org/10.3103/S0095452717030124

Sodium ferulate inhibits high­fat diet­induced inflammatory factors expression in human umbilical vein endothelial cells

Tao J.L., Zhang D.X., Man Y.H., Wang W., Bi Y.

  • School of public health, Wuhan University, Wuhan 430072, China
  • Nanyang Medical College, Nanyang 473000, China

Vascular inflammation is an important hallmark of atherosclerosis caused by high­fat diet. Oxidized low­density lipoprotein (ox­LDL) is a key initiator of in­flammation as it activates vascular endothelial cells to induce the expression of inflammatory genes. Sodium ferulate (SF), an active component from Chinese medicine, was reported to have potential of anti­athe­rosclerotic activity. However, little is known about the mechanism. In present research we investigated how SF changed the cellular gene expression profile and restored ox­LDL­triggered inflammation in HUVECs. Cellular gene expression profile, the production of inflammatory genes and NF­κB activation were investigated in hu­man umbilical vein endothelial cells with or without SF (5 µM) treatment after precondition with ox­LDL (50 µg/ml). Ox­LDL treatment increased the produc­tion of inflammatory factors, including IL­1β, CCL20, IL­6, IL­8 and CXCL1. SF stimulation modulated the translocation of NF­κB between cytoplasm and nucle­us, and alleviated the inflammatory response induced by ox­LDL. Collectively, SF appeared to be able to suppress the expression of inflammatory factors in ox­LDL­stimulated endothelial cells, and transcription factor NF­κB might be involved in such process.

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TSitologiya i Genetika
2017, vol. 51, no. 3, 79-81

Current Issue
Cytology and Genetics
2017, vol. 51, no. 3, 214–220,
doi: 10.3103/S0095452717030124

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