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Effect of expression of IGF-1 gene on skin wound healing in K14/miGF-1 transgenic mice with streptozotocin-induced diabetes
SUMMARY. One of the main factors that can exert influence on the position and rate of skin regeneration process is IGF-1. Morphological and molecular biological studies of skin wounds of FVB wild-type mice and transgenic animals K14/mIGF-1 with streptozotocin-induced diabetes were carried out. An increase of IGF-1 expression, area and thickness of the regenerating epithelium, the number of Mac-1+ cells in the wound in transgenic animals compared with wild-type was shown.
Key words: skin, wound healing, diabetes, IGF-1, the expression
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|Coded & Designed by Volodymyr Duplij||Modified 24.09.21|