Radiation induced modification of human somatic cells chromosomes sensitivity to the testing mutagenic exposure of bleomycin

The voluntary investigation of hidden chromosome instability in 53 persons with different intensity of radiation exposure had been carried pout using modified «G2-bleomycin sensitivity assay». In all examined groups the individual levels of chromosome injuries under identical bleomycin exposure varied in wide range and didnґt depend on their initial values in the intact cultures. Among control donors and individuals with low radiation exposure ~33 % hypersensitive persons had been identified that can be considered as genetically caused phenomenon. In patients recovered from acute radiation syndrome (57,9 %) persons expressed hidden chromosome instability. The data permit to assume that high doses of ionizing radiation can modify inherited human chromosomes susceptibility to mutagen exposure.

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