GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

Chakova N.N., Mikhalenko E.P., Polonetskaya S.N., Chebotareva N.V., Demidchik Yu.E., Zilko A.A., Kvitko O.V., Krupnova E.V.

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Carriers of GSTT1 gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTT1(–). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

Tsitologiya i Genetika 2009, vol. 43, no. 1, pp. 48-53

E-mail: n.chakova igc.bas-net.by

Chakova N.N., Mikhalenko E.P., Polonetskaya S.N., Chebotareva N.V., Demidchik Yu.E., Zilko A.A., Kvitko O.V., Krupnova E.V. GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients, Tsitol Genet., 2009, vol. 43, no. 1, pp. 48-53.