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Y-chromosome microdeletions as a prognostic marker of male infertility

Tirkus M.Ya, Makukh G.V., Zastavna D.V., Guleyuk N.L., Nakonechny A.Y., Stoyka B.R.

 


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The results of molecular-genetic study of Y-chromosome microdeletions in men with spermatogenesis failure and in patients with cryptorchism are presented. The molecular-genetic studies of regions AZFa, AZFb, AZFc in STS loci - sY84, sY86, sY127, sY134, sY254, sY255 and SRY gene have been performed. Y-chromosome microdeletions were detected in 13,3% infertile men with spermogram failure. The frequency of genetic (cyto- and molecular) abnormalities among boys with isolated cryptorchism was 4%. The results show the necessity of additional study of genetic factors of cryptorchism development.

Tsitologiya i Genetika 2008, vol. 42, no. 2, pp. 46-50



Tirkus M.Ya, Makukh G.V., Zastavna D.V., Guleyuk N.L., Nakonechny A.Y., Stoyka B.R. Y-chromosome microdeletions as a prognostic marker of male infertility, Tsitol Genet., 2008, vol. 42, no. 2, pp. 46-50.




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