The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients

Dosenko V.E., Mikhalchuk D., Zagoriy V.Yu., Parkhomenko A.N., Moibenko A.A.

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Large multifunctional protease LMP2 (Arg₆₀®His) and LMP7 (Lys₁₄₅®Gln) gene allelic polymorphism in 200 patients with acute coronary syndrome and in 80 practically healthy people was determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; Р > 0.05 by c²-test). Analysis of LMP7 gene polymorphism has shown that Lys/Lys – 89.5 %, Lys/Gln – 10.5 %, Gln/Gln – 0 % (in control group 93.8, 6.2, 0 % correspondingly; Р > 0.05). The data show that LMP2 and LMP7 gene polymorphism is not a risk factor of acute coronary syndrome in Ukrainian population.

Tsitologiya i Genetika 2005, vol. 39, no. 6, pp. 50-54

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Dosenko V.E., Mikhalchuk D., Zagoriy V.Yu., Parkhomenko A.N., Moibenko A.A. The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients, Tsitol Genet., 2005, vol. 39, no. 6, pp. 50-54.