Number of Aberrations per Aberrant Cell as a Parameter of Chromosome Instability. 2. Comparative Analysis of Effects Induced by Different Mutagenes genetic

Kutsokon N.K., Lazarenko L.M., Bezrukov V.F., Rashidov N.M., Grodzinsky D.M.

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The average number of aberrations per aberrant cell was concluded to carry out information on chromosome instability peculiarities induced by different mutagens as it was shown in our previous work. The purpose of the current study was to present comparative analysis of intercellular distribution of number of aberrations and their theoretical approximations. Distribution of numbers of aberrations per cell in Allium cepa L. and Allium fistulosum L. root tip cells induced by different mutagenic factors (γ-irradiation, thiotepa, formaldehyde and seed aging) have been studied. The results were approximated to theoretical Poisson, geometric and negative binomial distributions. The intercellular distribution of aberrations did not correspond to any of the used theoretical distributions when A. cepa seeds were γ-irradiated. There was some, but not regular, accordance with theoretical distributions when chemical mutagens thiotepa in A. cepa and formaldehyde in A. fistulosum and seed aging in both species were evaluated. During seed aging frequency of aberrant cells increased more quickly in A. fistulosum in comparison with A. cepa.

Tsitologiya i Genetika 2004, vol. 38, no. 1, pp. 55-62

Kutsokon N.K., Lazarenko L.M., Bezrukov V.F., Rashidov N.M., Grodzinsky D.M. Number of Aberrations per Aberrant Cell as a Parameter of Chromosome Instability. 2. Comparative Analysis of Effects Induced by Different Mutagenes genetic, Tsitol Genet., 2004, vol. 38, no. 1, pp. 55-62.