ISSN 0564-3783  



Main page
Contacts
Themes
Archive  
Themes
Subscription
Information to authors
Editorial board
Mobile version


Export citations
UNIMARC
BibTeX
RIS

Influence of tumor drug resistance phenotype on the dynamics of cisplatin-induced changes of rat peripheral lymphocyte chromatin structure in Guerin’s carcinoma

Chekhun V.F., Ganina K.P., Kulik G.I., Solianik G.I., Kunskaia L.N., Gushchenko N.N.

 




The correlation between the tumor drug sensitivity and the degree of lymphocyte interphase nuclei chromatin damages induced by cisplatin in rats was found using sensitive and resistant to cisplatin variants of Guerin’s carcinoma. Increased optical density of lymphocyte chromatin in first minutes after cisplatin injection both in rats without Guerin’s carcinoma and with sensitive to cisplatin variants of this tumor was observed. Lymphocyte chromatin structure remains unchanged in rats with cisplatin resistant carcinoma. Normal blood cells are suppose to change their sensitiveness to cisplatin under the humoral influence of the growing tumor in according with its phenotype.

Tsitologiya i Genetika 2000, vol. 34, no. 5, pp. 11-17



Chekhun V.F., Ganina K.P., Kulik G.I., Solianik G.I., Kunskaia L.N., Gushchenko N.N. Influence of tumor drug resistance phenotype on the dynamics of cisplatin-induced changes of rat peripheral lymphocyte chromatin structure in Guerin’s carcinoma, Tsitol Genet., 2000, vol. 34, no. 5, pp. 11-17.

Copyright© ICBGE 2002-2023 Coded & Designed by Volodymyr Duplij Modified 23.03.23