Гістондеацетилази є родиною ферментів, залучених до регуляції багатьох важливих процесів у клітинах рослин та тварин. Рослинні гістондеацетилази вивчені значно менше порівняно з людськими. В даному дослідженні увага була зосереджена на поглибленій характеристиці гістондеацетилаз двох модельних видів рослин – Arabidopsis thaliana та Oryza sativa. За допомогою аналізу філогенетичної спорідненості до їх відомих гомологів людини було встановлено близькість до трьох класів гістондеацетилаз людини. Виявлено, що найвищу спорідненість серед гістондеацетилаз різного еволюційного походження мають HDAC6 людини та HDA5 A. thaliana (43,6 % гомології). Результати структурного вирівнювання свідчать про консервативність каталітичних доменів та високу спорідненість інгібіторів до обох гістондеацетилаз. Високий рівень відомих інгібіторів гістондеацетилаз людини до HDA5 A. thaliana продемонстровано за допомогою ліганд-білкового докінгу. Отримані результати дозволяють припустити високу ефективність застосування інгібіторів гістондеацетилаз людини до гістондеацетилаз рослин з метою покращення регуляції процесів їх росту та розвитку, а також стійкості до стресових чинників.
Ключові слова: гістондеацетилази, Arabidopsis thaliana, Oryza sativa, класифікація за гомологією, молекулярний докінг, інгібітори
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