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Genetic polymorphisms of three DNA­repair genes (PRKDC, XPD, XRCC1) are related to colorectal cancer susceptibility

Atieh Hashemi, Fahimeh Baghbani­arani, Mona Sadat Larijani

Реферат статті 




РЕЗЮМЕ. Хоча конкретні причини колоректального раку (CRC) залишаються невідомими, повноцінна здатність до репарації ДНК може знижувати ризик цього злоякісного захворювання. Здатність до репарації ДНК може бути знижена через зміну генів, залучених до цього процесу. Це може вплинути на схильність до онкогенезу. Існує припущення, що однонуклеотидні поліморфізми (SNPs) декількох генів репарації ДНК можуть бути фактором ризику для схильності до CRC та його прогнозування. За використання методу ПЛР-ПДРФ ми провели дослідження «випадок-контроль» з метою генотипування 291 пацієнта з CRC та 140 здорових осіб для визначення варіантів генів PRKDC, XPD та XRCC1. Результати продемонстрували, що генотипи поліморфізму XRCC1 c.580C>T були пов’язані з ризиком CRC. Порівняно з CC, CT (коефіцієнт співвідношення ризиків (OR = 5,35, P < 0,001) та CT/TT (OR = 4,74, P < 0,001), а також алель T (OR = 4,95, P < 0,001) мали надмірне представлення серед пацієнтів з CRC. Варіантний генотип CC (OR = 2,37; P = 0,042) і алель C поліморфізму XPD c.2251A>C (OR = 1,37; P = 0,028) підвищували ризик випадків CRC. Порівняно з GG, позитивний зв’язок було також показано між всіма генотипами (GT, TT, GT/TT) поліморфізму PRKDC rs7003908; 6721G>T та CRC. Більше того, алель T PRKDC продемонстрував значний ризик щодо CRC (OR = 5,61; P < 0,001). Крім того, спостерігалась суттєва значимість варіацій PRKDC rs7003908; 6721G>T щодо паління, а також варіацій XPD c.2251A>C щодо споживання тютюнових та алкогольних виробів особами з CRC. Наші результати демонструють, що генетичні поліморфізми генів PRKDC, XRCC1, XPD можуть впливати на схильність до CRC серед населення Ірану.

Ключові слова: PRKDC, XPD, XRCC1, колоректальний рак, поліморфізми, схильність до раку

Цитологія і генетика 2020, том 54, № 4, C. 90-92

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. Department of Genetics & Biotechnology, School of Biological Science, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
  3. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran

E-mail: fbaghbani iauvaramin.ac.ir

Atieh Hashemi, Fahimeh Baghbani­arani, Mona Sadat Larijani Genetic polymorphisms of three DNA­repair genes (PRKDC, XPD, XRCC1) are related to colorectal cancer susceptibility, Цитологія і генетика., 2020, том 54, № 4, C. 90-92.

В "Cytology and Genetics". Якщо тільки можливо, цитуйте статтю по нашій англомовній версії:
Atieh Hashemi, Fahimeh Baghbani-arani & Mona Sadat Larijani Genetic Polymorphisms of Three DNA-Repair Genes (PRKDC, XPD, XRCC1) are Related to Colorectal Cancer Susceptibility, Cytol Genet., 2020, vol. 54, no. 4, pp. 363–371
DOI: 10.3103/S0095452720040040


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