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Genomic study of Covid­19 corona virus excludes its origin from recombination or characterized biological sources and suggests a role for hervs in its wide range symptoms

Ahmed M. El-Shehawi, Saqer S. Alotaibi, Mona M. Elseehy

Оригінальна работа 




РЕЗЮМЕ. COVID-19 – це викликане коронавірусом захворювання, яке переросло у всесвітню пандемію, початок якої було зафіксовано у грудні 2019 року у місті Ухань, Китай, але біологічне джерело якого не було підтверджено. У різних країнах повідомляли про геномну послідовність різних ізолятів, отриманих від інфікованих пацієнтів. Це дозволило нам загалом отримати 38 ізолятів повних геномних послідовностей. Вирівнювання нуклеотидної (nt) послідовності проводили за допомогою множинного вирівнювання Clustal Omega на веб-сайті Європейського інституту біоінформатики (EBI). Вирівнювання нуклеотидної послідовності і філогенетичний зв’язок показали, що COVID-19 – це новий штам віруса, біологічне походження якого ще не було встановлено. Очікувана структура orf була різною серед ізолятів, отриманих з однієї країни або різних країн, а також ізолятів SARS-CoV чи CoV кажанів, що дозволяє припустити різні можливості взаємодії віруса та людини під час інфікування та складності захворювання. Всі ізоляти мали п’ять основних orfs (1ab, S, M, N, E), однак, відрізнялися очікуваними допоміжними orfs. Оскільки біологічне джерело COVID-19 залишається невстановленим, було обговорено роль ендогенних ретровірусів людини (HERV) у регуляції експресії генів клітин господаря чи кодування продуктів, які можуть модулювати інфекцію COVID-19 і спектр її симптомів.

Ключові слова: COVID-19, геном, вирівнювання нуклеотидної послідовності, ендогенні ретровіруси людини (HERV)

Цитологія і генетика 2020, том 54, № 6, C. 75-78

  1. Department of Biotechnology, Faculty of Sciences, Taif University, 888 Taif, Kingdom of Saudi Arabia
  2. Department of Genetics, Faculty of Agriculture, University of Alexandria, Alexandria 21527, Egypt

E-mail: elshehawi hotmail.com, saqer-20 hotmail.com, monaahmedma yahoo.com

Ahmed M. El-Shehawi, Saqer S. Alotaibi, Mona M. Elseehy Genomic study of Covid­19 corona virus excludes its origin from recombination or characterized biological sources and suggests a role for hervs in its wide range symptoms, Цитологія і генетика., 2020, том 54, № 6, C. 75-78.

В "Cytology and Genetics". Якщо тільки можливо, цитуйте статтю по нашій англомовній версії:
Ahmed M. El-Shehawi, Saqer S. Alotaibi & Mona M. Elseehy Genomic Study of COVID-19 Corona Virus Excludes Its Origin from Recombination or Characterized Biological Sources and Suggests a Role for HERVS in Its Wide Range Symptoms, Cytol Genet., 2020, vol. 54, no. 6, pp. 588–604
DOI: 10.3103/S0095452720060031


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