Хронічна мієлоїдна лейкемія – це мієлопроліферативне новоутворення, що виникає внаслідок появи аномальних гемопоетичних стовбурових клітин, які несуть онкобілок Bcr-Abl, як результат реципрокної транслокації між 9 та 22 хромосомою. Основні елементи патогенезу захворювання обумовлені як підвищеною тирозинкіназною активністю білка Abl, так і роллю Bcr частини гібридного білка. Наявність РН домену в Bcr обумовлює його взаємодію з PI(3)P фагосомальної мембрани. Нами продемонстровано, що ця взаємодія супроводжується колокалізацією Bcr з білком FNBPI у фагосомах клітин макрофагів J774. Представлена модель впливу онкопротеїну Bcr-Abl на утворення надлишку АФК при ХМЛ за рахунок неконтрольованої експресії фагосомальної НАДФ-оксидази.
Ключові слова: хронічна мієлоїдна лейкемія, Bcr-Abl, FNBP1, фагосома, НАДФ-оксидаза
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