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Relationship between the prevalence of ACE1 I/D polymorphism genotype ii and COVID-19 morbidity, mortality in Ukraine and in some Europe countries

Livshits L.A., Harashchenko T.A., Umanets T.R., Krasnienkov D.S., Gorodna O.V., Podolskiy Vl.V., Kaminska T.M., Lapshyn V.F., Podolskiy V.V., Antipkin Yu.G.

 




SUMMARY. Coronavirus disease (COVID-19), which was first re-corded in China in December 2019, quickly spread to other countries and in a short period of time, the local outbreak escalated into a pandemic. There are significantly more cases of COVID-19 morbidity and mortality in European countries than in East Asia, where the disease was first detected. Such population differences are unique, especially for SARS-CoV-2 and are due to both socio-behavioral differences and features of the gene pool of the population of different countries. For infectious diseases, such as COVID-19, an important point is the genetic characteristics of individuals, which can determine its resistance or sus-ceptibility to infection. Therefore, studies of the factors of hereditary predisposition to SARS-CoV-2 infection, as well as severity and mortality are extremely relevant. After genotyping among the healthy population of Ukraine and collecting relevant data from some Euro-pean countries, we determined the correlation between morbidity, mortality from COVID-19 and the prevalence of genotype II in the populations of Ukraine and several European countries. There was a negative correlation between the carrier of genotype II and susceptibility to SARS-CoV-2 infection per 1 million population (R = 0.53, p < 0.05), so individuals with genotype II can be considered more resistant to infection SARS-CoV-2. Further study of the role of allelic variants of the ACE1 gene in the development of severity and complications affected patients of COVID-19, are promising for iden-tified of genetic markers for development of personalized therapy.

Key words: COVID-19, SARS-CoV-2, morbidity, ACE1 gene, hereditary predisposition

Tsitologiya i Genetika 2021, vol. 55, no. 5, pp. 28-35

  1. State Institution Institute of Pediatrics, Obstetrics and Gynecology named after Academician O.M. Lukyanova, National Academy of Medical Sciences of Ukraine, Platona Mayborody st., 8, Kyiv, 04050, Ukraine
  2. Institute of Molecular Biology and Genetics National Academy of Sciences of Ukraine, Zabolotnogo Str., 150, Kyiv, 03143, Ukraine
  3. State Institution Institute of Gerontology named after Dmitry F. Chebotarev, National Academy of Medical Sciences of Ukraine, Vyshgorodska Street, 67, 04114, Kyiv, Ukraine
  4. Kyiv City Childrens Clinical Hospital of Infectious Diseases, Dehtiarivska Street, 23, 04119, Kyiv, Ukraine

E-mail: livshits edu.imbg.org.ua, tatti.my gmail.com, tetiana.umanets gmail.com, krasnenkovd gmail.com, podolskyy.v ukr.net

Livshits L.A., Harashchenko T.A., Umanets T.R., Krasnienkov D.S., Gorodna O.V., Podolskiy Vl.V., Kaminska T.M., Lapshyn V.F., Podolskiy V.V., Antipkin Yu.G. Relationship between the prevalence of ACE1 I/D polymorphism genotype ii and COVID-19 morbidity, mortality in Ukraine and in some Europe countries, Tsitol Genet., 2021, vol. 55, no. 5, pp. 28-35.

In "Cytology and Genetics":
L. A. Livshits, T. A. Harashchenko, T. R. Umanets, D. S. Krasnienkov, O. V. Gorodna, Vl. V. Podolskiy, T. M. Kaminska, V. F. Lapshyn, V. V. Podolskiy & Yu. G. Antipkin Relationship between the Prevalence of ACE1 I/D Polymorphism Genotype II and Covid-19 Morbidity, Mortality in Ukraine and in Some Europe Countries, Cytol Genet., 2021, vol. 55, no. 5, pp. 427432
DOI: 10.3103/S0095452721050054


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