TSitologiya i Genetika 2025, vol. 59, no. 2, 65-75
Cytology and Genetics 2025, vol. 59, no. 2, 197–205, doi: https://www.doi.org/10.3103/S0095452725020094

Creation and application of the microRNA liposomal form for the treatment of neurodegenerative diseases

Shulga S., Andriiash H., Tigunova О., Priyomov S., Blume Ya.

  • Institute of Food Biotechnology and Genomics NAS of Ukraine, Baidy-Vyshnevetskoho str., 2a, Kyiv, 04123, Ukraine

SUMMARY. Target delivery of active pharmaceutical ingredients, including microRNAs, is an urgent problem. Using liposomes as target carriers of different therapeutic agents has some advantages and is becoming more widespread. Liposomes can transport both hydrophilic and hydrophobic molecules at the same time. Liposomes are relatively highly stable under physiological conditions, notable for the regulated release of the encapsulated ingredients, and biocompatible with cell membranes. Medications elaborated based on microRNA encapsulated into liposomes can become an alternative to classic therapeutic agents in treating neurodegenerative diseases. Neuroinflammation is known to be mediated via a complex interaction between the cells of the central nervous system (CNS) and the periphery. Although the inflammatory reaction in the healthy brain is under the strict control of numerous regulatory mechanisms, there may be a deregulation of these processes under pathology. This de-regulation leads to uncontrolled neuroinflammation. Among the main regulators of these processes, a relevant role is played by microRNAs, due to which the processes may become deregulated, promoting the disease progression, or may reflect the homeostatic attempt of the CNS to prevent excessive damage and restore normal conditions of functioning. The study summarizes the literature data about the creation, properties, and utilization of the liposomal form of microRNA, including microRNA-101, in the development of Alzheimer’s disease.

Keywords: neurodegenerative diseases, Alzheimer’s disease, therapeutic agents, microRNA, delivery, liposomes

TSitologiya i Genetika
2025, vol. 59, no. 2, 65-75

Current Issue
Cytology and Genetics
2025, vol. 59, no. 2, 197–205,
doi: 10.3103/S0095452725020094

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