TSitologiya i Genetika 2024, vol. 58, no. 1, 56-58
Cytology and Genetics 2024, vol. 58, no. 1, 53–59, doi: https://www.doi.org/https://doi.org/10.3103/S0095452724010092

Impact of different DNA ploidy patterns on endometrial carcinomas based on image cytometry

Kosmas K., Riga D., Karachaliou C., Papazian M., Sofopoulos M., Riga N.G., Tsiambas E.

  1. Department of Cytopathology, 417 Army Equity Fund Hospital (NIMTS), Athens, 115 21 Greece
  2. Department of Histopathology, “Ippokratio” General Hospital of Athens, 115 27 Greece
  3. Department of Gynaecology, 417 Army Equity Fund Hospital (NIMTS), Athens, 115 21 Greece
  4. Department of Pathology, 417 Army Equity Fund Hospital (NIMTS), Athens, 115 21 Greece
  5. Department of Histopathology, “Andreas Sygros” Hospital of Athens, 161 21 Greece

Worldwide, endometrial cancer is one of the most frequently diagnosed malignancies in women and a notable cause of death. The aim of this study was to perform image cytometric DNA ploidy analysis on a prospective material of endometrial adenocarcinomas in order to determine potential correlation between ploidy status and their histological features. The analysis was carried out in fresh tissue samples resected by implementing complete hysterectomy in a series of patients (n=126). We found that ploidy status using image cytometry correlate with histologic type, grade and stage in endometrial cancer and aneuploid tumor samples are associated with aggressive phenotype statistics. Furthermore, DNA ploidy should be used as a reliable and applicable prognostic marker in the routine clinical practice.

Keywords: DNA ploidy, Image cytometry, diploid, aneuploidy, endometrial carcinoma

TSitologiya i Genetika
2024, vol. 58, no. 1, 56-58

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Cytology and Genetics
2024, vol. 58, no. 1, 53–59,
doi: https://doi.org/10.3103/S0095452724010092

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