SUMMARY. Since the nanoscale combined with luminescent pro-perties and promising applications in various fields of optoelectronics and biomedicine leads to a growing interest in studying the features of cadmium telluride quantum dots, we have developed a method for the «green» synthesis of CdTe quantum dots using the mycelium culture of Pleurotus ostreatus as a biological matrix. The study of their physical and chemical characteristics revealed that the synthesized CdTe quantum dots have a predominantly spherical morphology and a size of 3–8 nm, a crystal structure, and a maximum luminescence in the range of 340–370 nm. When studying their effects on various types of mammalian cells, it was found that CdTe quantum dots have a dose-dependent effects on mouse endothelial cells, erythrocytes, human and rat T and B lymphocytes, colon cancer cells (Colo 205) and human breast cancer cells (MCF-7). In particular, we observed inhibition of endothelial cell proliferation and an increase in dead cells, indicating the cytotoxic effect of nanocrystalline CdTe and its antiproliferative effect on endothelial cells. CdTe quantum dots at a con-centration of 5 µM exhibited hemolytic activity when exposed to erythrocytes, affected adhesive contacts and survival of cancer cells. At the same time, human breast cancer cells (MCF-7) were more sensitive to their action. The data obtained are extremely important for understanding the mechanisms of toxicity of CdTe quantum dots for their further use in biological and biomedical research.
Keywords: «green synthesis», quantum dots, CdTe, toxicity, human cells, animal cells, cancer cell culture
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