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SEVENSINGLE NUCLEOTIDE POLYMORPHISM POLYGENIC RISK SCORE FOR BREAST CANCER RISK PREDICTION IN A VIETNAMESE POPULATION

T.T.N. Nguyen, T.H.N. Nguyen, H.N. Phan, H.T. Nguyen

 




Multiple common variations discovered via genomewide association studies (GWASs) were shown to have a minimal association with breast cancer (BC) risk in Vietnamese women. This study analyzed the cumulative effect in predicting BC risk of ten single nucleotide polymorphisms (SNPs) identified by previous GWAS and were common in Vietnamese. In this casecontrol research, 240 BC patients and 271 healthy controls were recruited to assess candidate SNPs association with BC risk. A polygenic risk score (PRS) was then created from SNPs strongly related to the risk of BC among the assessed population. The area under the receiver operating characteristic curve (AUC) was used to assess the effectiveness of the PRS model with BC risk. Logistic regression results showed seven individual SNPs (rs2155209, rs4784227, rs2605039, rs3817198, rs2981582, rs11614913, and rs12325489) were significantly associated with BC risk after multiple testing. These SNPs were then used to create the PRS model. Compared with women in the lowest quartile, women in the highest quartile of PRS had a considerably higher risk (odds ratio 2.65; 95 % confidence interval (95 % CI) 1.614.40) with AUC at 71 %. These findings suggest that the 7SNP PRS would effectively distinguish between women with high and low risk of BC, indicating the genetic marker for BC risk prediction in a Vietnamese population.

Key words: breast cancer risk; polygenic risk score; risk prediction model; single nucleotide polymorphism; Vietnam

Tsitologiya i Genetika 2022, vol. 56, no. 4, pp. 82-86

  1. Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City, Vietnam, 700000
  2. Vietnam National University, Ho Chi Minh City, Vietnam, 700000

E-mail: ngtnthanh hcmus.edu.vn

T.T.N. Nguyen, T.H.N. Nguyen, H.N. Phan, H.T. Nguyen SEVENSINGLE NUCLEOTIDE POLYMORPHISM POLYGENIC RISK SCORE FOR BREAST CANCER RISK PREDICTION IN A VIETNAMESE POPULATION, Tsitol Genet., 2022, vol. 56, no. 4, pp. 82-86.

In "Cytology and Genetics":
Thanh Thi Ngoc Nguyen, Thu Huynh Ngoc Nguyen, Hoang Ngo Phan & Hue Thi Nguyen Seven-Single Nucleotide Polymorphism Polygenic Risk Score for Breast Cancer Risk Prediction in a Vietnamese Population, Cytol Genet., 2022, vol. 56, no. 4, pp. 379390
DOI: 10.3103/S0095452722040065


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