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Comparative characteristics of cytogenetic anomalies in different types of myelodysplastic syndromes

Andreieva S.V., Korets K., Skorohod I., Starodub H.

 




SUMMARY. Comparison of cytogenetic and molecular-cytogenetic rearrangements of bone marrow cells in 251 patients at diagnosis of myelodysplastic syndromes (MDS) and in 7 - in the transformation into secondary acute myeloid leukemia was carry out. Significant heterogeneity of karyotypes in the structure of clones in all isolated forms of MDS and in transformed MDS into secondary acute myeloid leukemias was established and indicating a different genetic composition of bone marrow cells. It is shown that the evolution of clonal chromosome abnormalities is a universal mechanism for the formation of abnormal clones. An increase in the frequency of pseudodiploid and hypodiploid clones depending on the complexity of the form of MDS were marked: pseudodiploid from 4.5 % in MDS with single-line dysplasia (RA) to 27.3 % in MDS with excess blasts (RAEB 12), hypodiploid from 4.5 in RA to 18.2 at RAEB 12)were shown, which is associated with the loss of genetic material. In the group of RA losses of genetic material in the form of deletions (57.9 %) more often recorded. Chromosome 11 (31.6 %) was more often involved in structural rearrangements.

Key words: myelodysplastic syndromes, bone marrow, chromosome abnormalities

Tsitologiya i Genetika 2022, vol. 56, no. 5, pp. 32-40

E-mail: office immd.kiev.ua, Korets_Katya ukr.net, insk medlab.kiev.ua, gal.starodub gmail.com

Andreieva S.V., Korets K., Skorohod I., Starodub H. Comparative characteristics of cytogenetic anomalies in different types of myelodysplastic syndromes, Tsitol Genet., 2022, vol. 56, no. 5, pp. 32-40.

In "Cytology and Genetics":
S. V. Andreieva, K. V. Korets, I. M. Skorohod & H. S. Starodub Comparative Characteristics of Cytogenetic Abnormalities in Different Types of Myelodysplastic Syndromes, Cytol Genet., 2022, vol. 56, no. 5, pp. 423430
DOI: 10.3103/S0095452722050024


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