SUMMARY. Oxidative stress is one of the main reasons of severe complications development during diabetes mellitus (DM). Modern pharmacological drugs are able to lower blood glucose level but seldom possess antioxidant properties. There is data about broad specter of biological activity of photobiomodulation therapy (PBM therapy). Potential ability to decrease blood glucose concentration and antioxidant activity give this type of therapy a perspective application in treatment of DM and its complications. The effect of PBM therapy on antioxidant protection system of blood leukocytes in rats with streptozotocin-induced DM was studied. Established that irradiation of rats with DM cause the increasing of superoxide dismutase activity and normalization of oxidative stress markers (TBA-positive products, oxidatively modified proteins and advanced glycation end products).
Keywords: diabetes mellitus; photobiomodulation therapy; blood leukocytes; oxidative stress; antioxidant system
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