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The effect of photobiomodulation therapy on oxidative stress progressing in blood leukocytes of streptozotocin-induced diabetic rats

Karmash O.I., Liuta M.Ya., Korobov A.M., Sybirna N.O.


SUMMARY. Oxidative stress is one of the main reasons of severe complications development during diabetes mellitus (DM). Modern pharmacological drugs are able to lower blood glucose level but seldom possess antioxidant properties. There is data about broad specter of biological activity of photobiomodulation therapy (PBM therapy). Potential ability to decrease blood glucose concentration and antioxidant activity give this type of therapy a perspective application in treatment of DM and its complications. The effect of PBM therapy on antioxidant protection system of blood leukocytes in rats with streptozotocin-induced DM was studied. Established that irradiation of rats with DM cause the increasing of superoxide dismutase activity and normalization of oxidative stress markers (TBA-positive products, oxidatively modified proteins and advanced glycation end products).

Key words: diabetes mellitus; photobiomodulation therapy; blood leukocytes; oxidative stress; antioxidant system

Tsitologiya i Genetika 2020, vol. 54, no. 5, pp. 97-107

  1. Department of Biochemistry, Ivan Franko National University of Lviv, Lviv, Ukraine
  2. Laboratory of Quantum Biology and Quantum Medicine, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine

E-mail: sashakarmash

Karmash O.I., Liuta M.Ya., Korobov A.M., Sybirna N.O. The effect of photobiomodulation therapy on oxidative stress progressing in blood leukocytes of streptozotocin-induced diabetic rats, Tsitol Genet., 2020, vol. 54, no. 5, pp. 97-107.

In "Cytology and Genetics":
O. I. Karmash, M. Ya. Liuta, A. M. Korobov & N. O. Sybirna Effect of Photomodulation Therapy on Development of Oxidative Stress in Blood Leukocytes of Rats with Streptozocin-Induced Diabetes Mellitus, Cytol Genet., 2020, vol. 54, no. 5, pp. 456Ц464
DOI: 10.3103/S0095452720050114


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