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Effect of gene SFU1 on the riboflavin synthesis in flavinogenic yeast Candida famata

Petrovska Y., Lyzak O., Dmytruk K., Sibirny A.

 




SUMMARY. Riboflavin or vitamin B2 is a necessary component for all living organisms being the precursor of flavin coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide) involved in numerous enzymatic reactions. Flavinogenic yeast Candida famata overproduces riboflavin under iron starvation; however, regulation of this process is poorly understood. Regulatory gene SEF1 encoding transcription activator has been identified. Its deletion blocks yeast ability to overproduce riboflavin under iron starvation. It is known that in the pathogenic flavinogenic yeast C. albicans, Sfu1 (GATA-type transcription factor) represses SEF1. Here we found that deletion of SFU1 gene in wild type C. famata leads to riboflavin oversynthesis.

Tsitologiya i Genetika 2020, vol. 54, no. 5, pp. 39-44

  1. Institute of Cell Biology National Academy of Sciences of Ukraine, Drahomanov St., 14/16, Lviv, 79005, Ukraine
  2. Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
  3. University of Rzeszow, Zelwerowicza 4, 35-601 Rzeszow, Poland

E-mail: sibirny cellbiol.lviv.ua

Petrovska Y., Lyzak O., Dmytruk K., Sibirny A. Effect of gene SFU1 on the riboflavin synthesis in flavinogenic yeast Candida famata, Tsitol Genet., 2020, vol. 54, no. 5, pp. 39-44.

In "Cytology and Genetics":
Y. Petrovska, O. Lyzak, K. Dmytruk & A. Sibirny Effect of Gene SFU1 on Riboflavin Synthesis in Flavinogenic Yeast Candida famata, Cytol Genet., 2020, vol. 54, no. 5, pp. 408–412
DOI: 10.3103/S0095452720050060


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