TSitologiya i Genetika 2019, vol. 53, no. 5, 92-93
Cytology and Genetics 2019, vol. 53, no. 5, 424–429, doi: https://www.doi.org/10.3103/S0095452719050074

The P268S and M863V polymorphisms of the NOD2/CARD15 gene in Сrohn’s disease and ulcerative colitis

Songül Budak Diler, Fikriye Polat, Serkan Yaraş

  1. University of Niğde Ömer Halisdemir, Faculty of Science and Letters, Department of Biotechnology, Niğde, Turkey
  2. University of Kocaeli, Faculty of Education, Department of Mathematics and Sciences Education, Kocaeli, Turkey
  3. University of Mersin, Faculty of Medicine, Department of Gastroenterology, Mersin, Turkey

We aimed to determine P268S and M863V polymorphisms in NOD2/CARD15 genes associated with an increased risk of developing Crohn’s disease (CD) and ulcerative colitis (UC) and to establish correlations between P268S and M863V genotypes in Turkish population. This study included 152 healthy controls and 138 patients (62 CD and 76 UC) with IBD. Our results, the P268S CC genotype was prevalent on patients and controls (45 vs 66 %), followed by genotypes CT (48 vs 28 %) and TT (7 vs 6 %) in CD. The prevalence of genotypes of CC (wild-type), CT (heterozygous mutant) and TT (homozygous mutant) profiles for the P268S polymorphism were 68, 25 and 7 % respectively in UC patients, and 66, 28 and 6 % respectively in healthy control groups. We were found in wild-type M863V in all subjects and no other mutant band. P268S polymorphism may be associated with CD susceptibility in Turkish population, whereas there is not associated between M863V polymorphisms and patients with IBD in Turkish population.

Keywords: Ulcerative colitis, Crohn’s disease, NOD2/CARD15 gene, Single nucleotide polymorphism, RFLP

TSitologiya i Genetika
2019, vol. 53, no. 5, 92-93

Current Issue
Cytology and Genetics
2019, vol. 53, no. 5, 424–429,
doi: 10.3103/S0095452719050074

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