Allelic polymorphism C-590T of the gene IL-4 as the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children

SUMMARY. Molecular-genetic study of C-590T polymorphic locus of IL-4 gene in 31 children with recurrent episodes of acute obstructive bronchitis and 50 people who constituted the control population-based group has been carried out. It is proved that the presence of this polymorphic locus leads to three-fold increase of the risk of acute obstructive bronchitis recurrent episodes.

Keywords: recurrent episodes of acute obstructive bronchitis, acute respiratory infections, children, molecular genetic analysis, gene polymorphism