30 years of the Chernobyl accident. Molecular genetic mechanisms of carcinogenesis of thyroid gland

Tronko N.D., Pushkarev V.M.

SUMMARY. The review presents data on the basic molecular ge-netic mechanisms of formation of papillary thyroid carcinoma. The participation of ionizing radiation in the cancer pathogenesis was analyzed. The role of tu-mor microenvironment, inflammation and nuclear trans-cription factor NF-κB in the initiation and development of papillary thyroid carcinoma was shown.

Key words: thyroid, papillary carcinoma, oncogenes, ionizing radiation, inflammation, NF-κB
щитоподібна залоза, папілярна карцинома, онкогени, іонізуюча радіація, запалення, NF-κB

Tsitologiya i Genetika 2016, vol. 50, no. 6, pp. 15-22

E-mail: pushkarev.vm gmail.com

Tronko N.D., Pushkarev V.M. 30 years of the Chernobyl accident. Molecular genetic mechanisms of carcinogenesis of thyroid gland, Tsitol Genet., 2016, vol. 50, no. 6, pp. 15-22.

In "Cytology and Genetics":
N. D. Tronko, V. M. Pushkarev Thirty years after the Chernobyl accident: Molecular genetic mechanisms of carcinogenesis of the thyroid gland, Cytol Genet., 2016, vol. 50, no. 6, pp. 366–371
DOI: 10.3103/S0095452716060098