Effect of T­lymphocytes and interferon­gamma on the stages of multicellular tumor spheroids formation in vitro

Perepelytsina O., Gergeliuk T., Sydorenko M.

SUMMARY. In our work we studied the effect of T lymphocytes and interferon-gamma on the vital activity of the breast cancer cells population and formation of multicellular tumor spheroids. We demonstrated the stages of multicellular tumor spheroids formation and the possible ways to implement antitumor influence of T lymphocytes and interferon-gamma through a change in estrogen receptor and the epidermal growth factor receptor expression. Our results shown a cor-relation between the type of humoral influance, the degree of expression of estrogen receptor and epider-mal growth factor receptor and the intensity of tumor microaggregates formation.

Key words: multicellular tumor spheroids, T lymphocytes, interferon gamma, estrogen receptor, epidermal growth factor receptor

Tsitologiya i Genetika 2014, vol. 48, no. 5, pp. 18-25

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Perepelytsina O., Gergeliuk T., Sydorenko M. Effect of T­lymphocytes and interferon­gamma on the stages of multicellular tumor spheroids formation in vitro, Tsitol Genet., 2014, vol. 48, no. 5, pp. 18-25.