Evaluation of genome stability and mitochondrial potential of tumor cells in vivo upon the action of nanoferromagnetics with different sizes of nanoparticles

Lozovskaya Yu.V., Todor I.N., Lukyanova N.Yu., Yefimova S.L., Borovoy I.A., Malyukin Y.V., Chekhun V.F.

SUMMARY. Genome stability and transmembrane potential of tumor cells from animals bearing ascite Ehrlich carcinoma upon the action of nanoferromagnetics with different sizes of nanoparticles were studied in comparative aspect. It has been shown that nanoferromagnetics with diameter of nanoparticles of 40 and 100 nm at the concentration of 3 mg/kg do not alter significantly mitochondrial transmembrane potential and tumor cell genome. Oppositely directed character of alteration of these indexes has been registered if nanoferromagnetics at the concentration of 6 mg/kg have been used. It has been shown that iron nanoparticles of smaller sizes caused an increase of mitochondrial transmembrane potential in tumor cells on the background of unaltered quantity of micronuclei while these of larger diameter caused the opposite effects. The obtained results point on different ways of influence of iron nanoparticles dependent on their sizes on mentioned above indexes in vivo.

Key words: nanoferromagnetic, mitochondrial transmembrane potential, micronuclei, tumor cells, iron nanoparticles, ascite Ehrlich carcinoma.

Tsitologiya i Genetika 2013, vol. 47, no. 4, pp. 46-52

E-mail: Lozovskaya.2012 mail.ru

Lozovskaya Yu.V., Todor I.N., Lukyanova N.Yu., Yefimova S.L., Borovoy I.A., Malyukin Y.V., Chekhun V.F. Evaluation of genome stability and mitochondrial potential of tumor cells in vivo upon the action of nanoferromagnetics with different sizes of nanoparticles, Tsitol Genet., 2013, vol. 47, no. 4, pp. 46-52.