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Cyclooxigenase-1 gene polymorphism and aspirin resistance
SUMMARY. The literature data concerning structure of cyclooxigenase-1 Ц the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.
Key words: cyclooxigenase-1, thromboxane, polymorphism of cyclooxigenase-1 gene, platelets aggregation, aspirin, aspirin resistance
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