Relationship of Toll-like receptors 2 and 4 genes polymorphisms with allergic diseases with increased levels of specific ige

Koutsenko N.L., Izmailova O.V., Vesnina L.E., Kaidashev I.P.

SUMMARY. The aim of the research was to identify the role of genes polymorphisms encoding TLR2 (NP_003255.2) and TLR4 (NP_612564.1) in the increase of the specific IgE production level and development of allergic diseases. Genetic typing of genome specific regions was performed by polymerase chain reaction method using specific oligonucleotide primers. The obtained results display that the most significant causative allergens are epidermal and household allergens (epidermis of cat, dog and horse, D. farinae, D. pteronyssinus). The relationship of polymorphisms TLR2 (rs5743708) and TLR4 (rs4986790) with increased production of specific IgE in patients with allergic diseases was also observed.

Key words: gene, polymorphism, Toll-like receptor, allergic disease, specific immunoglobulins E

Tsitologiya i Genetika 2012, vol. 46, no. 6, pp. 59-66

E-mail: congres2007 yandex.ru

Koutsenko N.L., Izmailova O.V., Vesnina L.E., Kaidashev I.P. Relationship of Toll-like receptors 2 and 4 genes polymorphisms with allergic diseases with increased levels of specific ige, Tsitol Genet., 2012, vol. 46, no. 6, pp. 59-66.

In "Cytology and Genetics":
N. L. Kutsenko, O. V. Izmailova, L. E. Vesnina, I. P. Kaidashev Role of toll-like receptor 2 and 4 gene polymorphisms in the development of allergic diseases with increased IgE levels, Cytol Genet., 2012, vol. 46, no. 6, pp. 379-383
DOI: 10.3103/S0095452712060072