Lewis lung carcinoma variant with high sensitivity to antitumor antiangiogenic therapy reveals a high capacity to autophagy

Kolesnik D.L., Pyaskovskaya O.N., Tregubova N.A., Solyanik G.I.

SUMMARY. Comparative investigation of two variants of Lewis lung carcinoma cells (LLC and LLC/R9) growing under nutrient deficiency caused by long-term incubation without growth medium replacement was performed. It was established that LLC/R9 cells which in contrast to LLC cells had a high sensitivity to antitumor antiangiogenic therapy (AAT) revealed a high dependence of their survival from glucose level in growth medium as well as high capacity to autophagy under nutrient deficiency. Perhaps high autophagy activity in tumor cells may be considered as a marker of tumor AAT sensitivity.

Key words: Lewis lung carcinoma, anticancer antiangiogenic therapy, metabolic stress, nutrient deficiency, autophagy

Tsitologiya i Genetika 2012, vol. 46, no. 3, pp. 33-40

Інститут експериментальної патології, онкології та радіобіології ім. Р.Є. Кавецького НАН України, Київ

E-mail: gsolyanik gmail.com

Kolesnik D.L., Pyaskovskaya O.N., Tregubova N.A., Solyanik G.I. Lewis lung carcinoma variant with high sensitivity to antitumor antiangiogenic therapy reveals a high capacity to autophagy, Tsitol Genet., 2012, vol. 46, no. 3, pp. 33-40.

In "Cytology and Genetics":
D. L. Kolesnik, O. N. Pyaskovskaya, N. V. Tregubova, G. I. Solyanik Lewis lung carcinoma variant with a high sensitivity to antitumor antiangiogenic therapy exhibits a high capacity for autophagy, Cytol Genet., 2012, vol. 46, no. 3, pp. 155-160
DOI: 10.3103/S009545271203005X