The role of PPARs and his isoforms in the metabolic disorder related to insulin resistance and diabetes

ISSN 0564-3783

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The role of PPARs and his isoforms in the metabolic disorder related to insulin resistance and diabetes

Kravchenko N.A., Yarmish N.V.

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PPARs play the key role in energy homeostasis, inflammation, development of insulin resistance, metabolic syndrome, therefore the special attention is spared to synthesis of the ligand PPARs (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by the fatty acids and their derivatives – eukosanoides. Polymorphism of the Pro12Ala gene PPARG2 affects the sensitiveness of tissues to insulin and the risk of the development diabetes. It is assumed that the PPAR polymorphism is related to the differential answer on pharmacotherapy that is the foundation for development of the personification of the drug application and the estimate of prognosis.

Key words: polymorphism of PPARs gene, insulinoresistentance, obesity, diabetes, lipids

Tsitologiya i Genetika 2011, vol. 45, no. 3, pp. 68-77

E-mail: zventa1957 mail.ru, zventa1957 yandex.ru

Kravchenko N.A., Yarmish N.V. The role of PPARs and his isoforms in the metabolic disorder related to insulin resistance and diabetes, Tsitol Genet., 2011, vol. 45, no. 3, pp. 68-77.

In "Cytology and Genetics":
N. A. Kravchenko, N. V. Yarmysh Role of PPARs and their isoforms in metabolic disorders related to insulin resistance and diabetes, Cytol Genet., 2011, vol. 45, no. 3, pp. 191-199
DOI: 10.3103/S0095452711030042

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Modified 29.05.23