Relationship of TLR2 and TLR4 gene polymorphism with a penchant for individual urogenital infections

Izmaylova O.V., Shlykova O.A., Bobrova N.A., Kaidashev I.P.

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We investigated the population prevalence of polymorphisms of Arg753Gln TLR2 gene, and Asp299Gly, Thr399Ile TLR4 genes among people living in the Poltava region, as well as data communication polymorphisms with the presence of diseases caused by urogenital infections. The group of population control was a random sample of residents of the Poltava region (n = 299). The group of patients with urogenital diseases included 156 people. Genotyping of these groups TLR2 Arg753Gln polymorphism and the gene TLR4 Asp299Gly, Thr399Ile was performed using PCR and subsequent restriction analysis. Statistically significant association of allele A of gene TLR2 (p = 0.0018) and allele G of gene TLR4 (p = 0.085) with the presence of urogenital diseases was confirmed.

Key words: gene, polymorphism, Toll-like receptor, urogenital infections

Tsitologiya i Genetika 2011, vol. 45, no. 4, pp. 29-35

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Izmaylova O.V., Shlykova O.A., Bobrova N.A., Kaidashev I.P. Relationship of TLR2 and TLR4 gene polymorphism with a penchant for individual urogenital infections, Tsitol Genet., 2011, vol. 45, no. 4, pp. 29-35.

In "Cytology and Genetics":
O. V. Izmailova, O. A. Shlykova, N. O. Bobrova, I. P. Kaidashev Relationship between the TLR2 and TLR4 gene polymorphisms with a predisposition to certain urogenital infections, Cytol Genet., 2011, vol. 45, no. 4, pp. 225-230
DOI: 10.3103/S0095452711040050