Single nucleotide polymorphism of +276G>T adiponectine (APМ1) gene in donors of Kharkiv population

Polymorphism of adiponectine (APM1) gene in +276G>T position was studied. For this research we used blood samples of 103 donors (men/women: 65/38; 70 Ukrainian, 33 Russian) – habitants of Kharkiv. Frequencies of Т and G alleles were р_T =0,55 and р_G =0,45 in a general group. They did not meaningfully differentiate either for men and women or for Russians and Ukrainians. Distributiоn of genotypes did not correspond to Hardy-Weinberg equilibrium: share of heterozygotes was 1.55 times higher than selectively-neutral value, share of TT homozygote is 0.55, and GG homozygote is 0.33 of equilibrium value.

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