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Genetic factors of male infertility. The role of complex examination in the cases of different spermatogenesis disturbances
Data about some male infertility genetic factors is presented and methods that can be used for its diagnostics are considered. Among genetic factors changes of the genetic apparatus at gene level (mutations), chromosome level (chromosomal aberrations), and total DNA (chromatin dispersion, DNA fragmentation) are pointed out. Beside standard cytogenetic diagnostic techniques, spermogram and DNA diagnostics, there are a number of molecular-cytogenetic methods (FISH, TUNEL, SCSA, SCGE, SCD). Profound studying of infertile men sperm at several levels of the genetic material organization will allow to estimate the informativity of each method separately and in a complex, and also to develop optimal algorithm for diagnostics performance with the aim of selection of the most effective treatment for male infertility.
Tsitologiya i Genetika 2009, vol. 43, no. 5, pp. 77-84
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