Polymorphism of paraoxonase (PON-1) gene in Slavonic part of Kharkiv population

Pochernyaev A.K., Tyzhnenko T.V., Gorshunska M.Yu., Poltorak V.V., Atramentova L.A.

Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 related to the synthesis of allozymes R or Q was studied. For this research we used blood samples of 109 donors (men/women: 78/31; 84 Ukrainian, 25 Russian) – habitants of Kharkiv. Frequency of Q and R alleles were р_Q = 0,67, р_R = 0,33. Distinctions of allele frequencies among Ukrainians and Russians and also among men and women were not significant. Distributing of genotype frequencies in the Slavonic population of Kharkiv corresponds to panmictic population.

Key words: Paraoxonase, polymorphism, gene

Tsitologiya i Genetika 2009, vol. 43, no. 5, pp. 64-68

E-mail: wshkoda23 rambler.ru, pochernyaev.ak84 m

Pochernyaev A.K., Tyzhnenko T.V., Gorshunska M.Yu., Poltorak V.V., Atramentova L.A. Polymorphism of paraoxonase (PON-1) gene in Slavonic part of Kharkiv population, Tsitol Genet., 2009, vol. 43, no. 5, pp. 64-68.