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Remyelination properties of human embryonic nerve cells in the course of long-term culture
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We have examined the mitogenic and differentiation potential and remyelination properties of human embryonic nerve cells in culture. After 1 month of cultivation without differentiation agents CNP-positive cells (the mitotically-active precursors of olygodendrocytes) were expanded at 3,6 times. At the same time the amount of GalC-positive cells (mature oligodendrocyres) remained low. So, the remyelination properties of embryonic nerve cells can be explained by high concentration of olygodendrocyte precursors. Cell population after cultivation maintained the increased remielination potential by increasing the number of CNP-positive cells that was confirmed by using experimental demyelination.
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