Androgen receptor cag gene polymorphism among azoospermic and oligozoospermic men from Ukraine

Fesai O.A., Kravchenko S.A., Tyrkus M.Ya., Makuh G.V., Zinchenko V.M., Strelko G.V., Livshits L.A.

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The number of CAG repeats of exon 1 of AR gene was determined in a group of 228 infertile males with azoospermia (n = 68) and oligozoospermia (n = 160) as well as in control group (124 proven fathers) by fluorescent polymerase chain reaction amplification followed by fragment analysis on automated fluorescent analyzer «A.L.F.-express». The frequency of alleles with CAG-repeats ≤18 was significantly higher (Р < 0,01) in the group of patients with azoospermia (17,7 %) comparing with the control group (2,4 %) as well as in the group of patients with oligozoospermia (12,5 %) comparing with the control group (2,4 %). The frequency of alleles with CAG-repeats ≥28 significantly differed (Р < 0,01) between the group of patients with oligozoospermia (12,5 %) and the control group (2,4 %). Our data suggest an association between CAG repeats number and impaired spermatogenesis in azoospermic and oligozoospermic males.

Tsitologiya i Genetika 2009, vol. 43, no. 6, pp. 45-51

Fesai O.A., Kravchenko S.A., Tyrkus M.Ya., Makuh G.V., Zinchenko V.M., Strelko G.V., Livshits L.A. Androgen receptor cag gene polymorphism among azoospermic and oligozoospermic men from Ukraine, Tsitol Genet., 2009, vol. 43, no. 6, pp. 45-51.