Frequency of the Pro12Ala gene polymorphism PPARγ2 in ukrainian population and its possible role in metabolic syndrome development

Kaydashev I.P., Rasin A.M., Shlykova O.A., Gorbas I.M., Smirnova I.P., Petrushov A.V., Rasin M.S.

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Frequency of the Pro12Ala gene polymorphism PPARγ2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40–65 years in Ukrainian population. The frequencies were 27,4 % for 12Аlа allele, 30,8 % for Pro12Ala, and 5,1 % for Аlа12Аlа that is close to the results of estimation of Czech population. The frequency of 12Аlа allele was significantly less – 20 % (p < 0,05) in the persons with MS that corresponds to the pre-established information concerning the patients with diabetes of the 2^nd type. A tendency has been detected to the increase of the body mass index in patients with 12Ala allele in the metabolic syndrome group.

Tsitologiya i Genetika 2007, vol. 41, no. 5, pp. 43-47

Kaydashev I.P., Rasin A.M., Shlykova O.A., Gorbas I.M., Smirnova I.P., Petrushov A.V., Rasin M.S. Frequency of the Pro12Ala gene polymorphism PPARγ2 in ukrainian population and its possible role in metabolic syndrome development, Tsitol Genet., 2007, vol. 41, no. 5, pp. 43-47.