Information to authors
Distribution of single nucleotide polymorphisms of IL-10 gene in cystic fibrosis patients
[Free Full Text (pdf)]
Distribution of interleukin-10 promoter –1082 G®A single nucleotide polimorphism (SNP) in the group of cystic fibrosis (CF) patients has been studied. As a whole 42 ÑF patients and 73 persons of the control group were genotyped for IL-10 promoter –1082 G®A SNP. The frequences of IL-10 –1082 G-allele and GG high expression genotype increased significantly in CF patients in comparison to the control group. In addition, study of IL-10 –1082 SNP distribution in the separate CF groups showed statistically significant increasing of the G-allele and GG-genotype frequencies in the subgroup of homozygous delF508 cariers. The possible role of IL-10 promoter SNP as a phenotype modifiers at different CF genotypes is examined.
Tsitologiya i Genetika 2006, vol. 40, no. 3, pp. 40-44
|Coded & Designed by Volodymyr Duplij||Modified 23.03.23|