ISSN 0564-3783  



Main page
Contacts
Preview papers  
Themes
Contents  
Themes
Subscription
Information to authors
Editorial board
Mobile version


In Russian

Export citations
UNIMARC
BibTeX
RIS





Variations of certain Biochemical blood parameters, cytokine and adypokine profiles, structural and functional parameters of the liver in nonalcoholic fatty liver disease patients with different genotypes by the polymorphic locus A313G of GSTP1 gen

Prysyazhnyuk V.P., Rossokha Z.I., Gorovenko N.G.

 




SUUMARY. The variations of certain biochemical blood parameters, cytokine and adypokine profiles, structural and functional parameters of the liver in nonalcoholic fatty liver disease patients with different genotypes by the polymorphic locus A313G of GSTP1 gene were investigated. G-allele of the GSTP1 gene (A313G) occured significantly more frequently in nonalcoholic fatty liver disease patients as compared to practically healthy individuals. Elevated alanineaminotransferase activity, higher leptin and lower adiponectin blood levels were observed in patients with G-allele in comparison with the corresponding figures in patients with AA-genotype. Nonalcoholic fatty liver disease patients G-allele homozygous carriers also experienced higher interleukin 10 blood level than patients with AA- and AG-genotypes. Larger right lobe of the liver was detected in patients with G-allele as compared to patients A-allele homozygous carriers.

Key words: glutathione-S-transferase P1 gene, nonalcoholic fatty liver disease

Tsitologiya i Genetika 2017, vol. 51, no. 6, pp. 50-57

E-mail: zoiroh071 gmail.com

Prysyazhnyuk V.P., Rossokha Z.I., Gorovenko N.G. Variations of certain Biochemical blood parameters, cytokine and adypokine profiles, structural and functional parameters of the liver in nonalcoholic fatty liver disease patients with different genotypes by the polymorphic locus A313G of GSTP1 gen, Tsitol Genet., 2017, vol. 51, no. 6, pp. 50-57.




Copyright© ICBGE 2002-2018 Coded & Designed by Volodymyr Duplij Modified 21.07.18