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Allelic polymorphism C-590T of the gene IL-4 as the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children

Kens O., Vishtak N., Acopyan H., Bergtravm V.

 




SUMMARY. Molecular-genetic study of C-590T polymorphic locus of IL-4 gene in 31 children with recurrent episodes of acute obstructive bronchitis and 50 people who constituted the control population-based group has been carried out. It is proved that the presence of this polymorphic locus leads to three-fold increase of the risk of acute obstructive bronchitis recurrent episodes.

Key words: recurrent episodes of acute obstructive bronchitis, acute respiratory infections, children, molecular genetic analysis, gene polymorphism

Tsitologiya i Genetika 2016, vol. 50, no. 3, pp. 30-35

E-mail: kensle mail.ru

Kens O., Vishtak N., Acopyan H., Bergtravm V. Allelic polymorphism C-590T of the gene IL-4 as the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children, Tsitol Genet., 2016, vol. 50, no. 3, pp. 30-35.

In "Cytology and Genetics":
O. V. Kens, N. V. Vishtak, H. R. Acopyan, V. I. Bergtravm Allelic polymorphism C-590T of the IL4 gene as a probable genetic marker for the increased predisposition to the development of recurrent episodes of acute obstructive bronchitis in children, Cytol Genet., 2016, vol. 20, no. 3, pp. 173–177
DOI: 10.3103/S0095452716030051


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